Abstract
This short communication deals with an 8-year-old boy with acute lymphocytic leukemia in third remission. He was initially planned to perform allogeneic bone marrow transplantation (BMT) from his HLA-identical and MLC-negative sibling in his CR3. However, he could not tolerate the conditioning regimen of high dose AraC because of increasing liver dysfunction and jaundice. Subsequently, he was diagnosed as having chronic active type C viral hepatitis by his liver biopsy and HCV-RNA positive result by the polymerase chain reaction (PCR) method. He was treated with interferon-α, to which he tolerated well and showed rapid clinical and laboratory improvement in terms of liver dysfunction. BMT was finally carried out using cyclophosphamide (CY) + total body irradiation (TBI) as conditioning regimen, when his liver function was almost normal and HCV-RNA became negative. During and after the preconditioning period, his liver function was stable and veno-occlusive disease (VOD) did not happen. We conclude that interferons therapy would be a choice of treatment for BMT recipient who was complicated with active type C viral hepatitis.
