Abstract
To a 7-year-old boy with AML during 1st complete remission we performed the bone marrow transplantation in 1988 from his HLA identical younger sister. In bone marrow harvesting we diagnosed her as malignant hyperthermia under general anesthesia with succinylcholine. We continued bone marrow harvesting after changing anesthesia into intravenous anesthesia with ketamine, but sequela did not remain. Although he had been in complete remission for 7 months, AML relapsed. After chemotherapy 2nd complete remission did not occur and bone marrow suppression was severe. We decided 2nd BMT to attain remission and harvested her bone marrow again before 2nd BMT using neuroleptanesthesia. In 2nd bone marrow harvesting, there was no trouble. Her bone marrow was cryopreserved and he received bone marrow transplantation after 114 days of her bone marrow harvesting. But he died of sepsis after 43 days of 2nd BMT. Anesthesia for BMT donor is necessary to be safe. This is a valuable case suggesting important problems we must consider in safety of BMT donor, especially in bone marrow bank system that started in Japan in 1992.
