Abstract
The Bone Marrow Transplantation Committee of the Society has conducted an annual registry of bone marrow transplantation in children in Japan since 1983. As of June 30, 1994, 2, 166 patients had received stem-cell transplantation and were registered from 100 institutions. Among them, autologous bone marrow transplantation was performed in 543 children (292 alive) and peripheral blood stem-cell transplantation was done in 357 children (224 alive). Allogeneic or syngeneic bone marrow transplantation were given to 1, 229children : 375 cases of acute lymphoblastic leukemia (190 alive), 302 cases of acute myeloid leukemia (188 alive), 79 cases of adult-type chronic myelocytic leukemia (49 alive), 7 cases of juvenile-type chronic myelocytic leukemia (3 alive), 47 cases of non-Hodgkin's lymphoma (34 alive), 37 cases of malignant solid tumors (17 alive), 215 cases of severe aplastic anemia (188 alive), 39 cases of severe combined immune deficiency (19 alive), and 128 other cases (81 alive). The total number of transplanted cases has increased from 1, 735 to 2, 166 during the past one year. Unrelated bone marrow transplantation from “donor bank” donors was performed in 54 children, with an overall actuarial disease-free survival rate of 48.1 ± 15.8%. The details are reported in this paper.
