Signal Transduction in Neutrophils

Biochemistry in Bactericidal Ability and Motility

Abstract

The neutrophilic leukocyte has proved to be a valuable model for studying signal transduction pathways. Neutrophil responses proceed from recognition of appropriate stimuli to an activation phase that initiates the terminal activation sequences involving activated NADPH oxidase, chemotaxis, and enzyme secretion. Oxidase activation in neutrophils involves the assembly, in the plasma membrane, of membrane-bound and cytosolic components of the oxidase complex, which were disassembled in their resting state. Chemotaxis involves actin, microtubles and plasma protein (ex. gelsolin). In these processes, tyrosine phosphorylation, G-protein and activation of phospholipases play important roles. The present review is focused on recent data concerning the signaling pathways which lead to oxidase activation and cellular motility, including pathogenesis and the biochemical aspects of diseases.