Abstract
We examined the combined effects of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) on CPU-GM colony and recovery of granulocyte count after allogenic bone marrow transplantation. Admixture of G-CSF and M-CSF increased the number of CFU-GM colonies (139 ± 61.7) to a greater extent than admixture of G-CSF (66.7 ± 38.8) or M-CSF (64.6 ±27.9) alone. Moreover, the numbers of CPU-GM stimulated by G-CSF and M-CSF together were greater than the sum of CFU-GM stimulated by G-CSF and M-CSF alone. When G-CSF and M-CSF were administered together after allogenic bone marrow transplantation, the granulocyte count recovered by day 11. These data suggested that G-CSF and M-CSF may be administered simultaneously when prompt recovery of granulocytes is required.
