Abstract
We present the cases of four children with advanced rhabdomyosarcoma (RMS) treated with double or triple PBSCT, because of the inability to undergo multidisciplinary treatment or refractory disease. They underwent PBSCT after 6-7 courses of conventional chemotherapy. Hematopoietic recovery in neutrophils even after the 2nd or 3rd course of PBSCT was very rapid and the regimen-related toxicities in every transplant were mild. Two out of 4 patients relapsed but 2 are still alive and disease-free. Repeated PBSCT is a feasible treatment. Multidisciplinary treatment including surgery, radiotherapy and chemotherapy combined with repeated PBSCT may be efficacious and useful for advanced RMS.
