Abstract
The purpose of this study was to clarify the relationship between the inner-diameter of an ampoule and the amount of glass particle accumulation after opening ampoules.All of the ampoules used in the study were snapped open by hand and left to stand undisturbed for 120 seconds.Tilting the ampoules,the solutions in them were aspirated using an 18 G nonfiltered needle attached to a 5 mL syringe.The contents of the ampoules were then diluted with 0.6-4 mL distilled water and passed through a 0.20 mm membrane filter.Amounts of remaining particles were measured using a KL-04 particle counter after aspiration of the ampoule contents.Our results suggested that glass particulate contamination was positively correlated with the inner-diameter of the ampoule,but not with the thickness of the ampoule walls.This finding could help prevent the injection of glass particles into patients,and the use of filters may further decrease the risk of this happening.
