Compatibility of Heparin Sodium in Intravenous Line with Nicardipine Injected from a Side Tube via T-shape Stopcock

Abstract

The compatibility caused by injection of Nicarpine^® 10 mg / 10 mL (Nicarpine^®) from a side tube into an intravenous line infused with Replas^® 1 Injection (Replas^® 1) and Novo-Heparin^® 10,000 units / 10 mL for Injection (Novo-Heparin^®) was investigated. We observed a mixed solution of each constituent of Replas^® 1 and Novo-Heparin^® with Nicarpine^®, and measured the IR spectrum of the precipitate and the ¹H-NMR spectrum of a saturated solution of the mixture of heparin and nicardipine. Our findings suggested that the compatibility was caused by an intermolecular interaction between heparin and nicardipine when in a 1:2 ration via the formation of a salt between the sulfate group and/or the carboxylic group of heparin and the amino group of nicardipine.