Abstract
The dissolution rate control of nateglinide from matrix granules was investigated under a sink condition. Nateglinide/hydrogenated castor oil (HCO) matrix granules showed pH dependent dissolution profiles. By adding calcium chloride (CaCl2) to nateglinide/HCO matrix granules, the pH dependence of the dissolution profile was reduced. Furthermore, it was confirmed that the nateglinide/HCO matrix granules containing CaCl2 decreased both postprandial blood glucose level and fasting blood glucose level in normal beagle dogs. These findings are considered to be useful in order to design a nateglinide sustained release formulation.
