Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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The Influence of Statin Treatment on the Effect of Sitagliptin in Obese Patients with Diabetes
Yuka Onoue, Naotake Takase, Shunichi Gouda, Keisuke Yonezawa, Toru Shinmen, Masayo Shioe, Ikuko Miki, Hisae Nakata, Toshiyuki Obata, Noriko Takahara, Nobuyuki Muroi
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Keywords: DPP-4inhibitor, sitagliptin, HMG-CoA inhibitor, obesity, insulin resistance
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2015 Volume 41 Issue 11 Pages 821-826

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Abstract

This study investigated the influence of treatment with statins on the effect of sitagliptin in obese patients with diabetes.
We studied 52 patients with type 2 obese diabetes who were started on sitagliptin from April 1, 2010 to March 31, 2012. Of these patients, 31 were taking a statin and 21 were not. HbA1c levels were measured at 0 and 3, 6, and 9 months after initiation of sitagliptin.
In obese patients (BMI ≧ 25 kg/m2), a significant improvement in HbA1c levels was observed only in those taking statins.
Our findings suggest that statins may modify the glucose-lowering effect of sitagliptin in obese patients with type 2 diabetes.

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© 2015 Japanese Society of Pharmaceutical Health Care and Sciences
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