Association between the Incidence of Chemotherapy with Cisplatin and Fluorouracil-induced Vomiting and the Body's Water Balance

Abstract

In a cisplatin (a highly emetogenic anti-cancer agent)-containing regimen, administrations of fluid replacement and/or of diuretic drugs are performed to relieve nephrotoxicity. Such treatments will alter the body's water balance, which may be partially responsible for chemotherapy-induced vomiting progression. We thus examined whether the body's water balance correlates with the incidence of chemotherapy-induced vomiting and/or the risk factors of chemotherapy-induced nausea and vomiting (CINV) in women (a CINV risk factor) inpatients receiving treatment with a cisplatincontaining regimen. The severity of chemotherapy-induced vomiting was significantly associated with increased body water in the patients with multiple (double), but not single CINV risk factors. Therefore, our findings suggest that the severity of chemotherapy-induced vomiting is decreased by keeping the body water balance constantly by restriction of hydration (eg short hydration) and/or consolidation of antiemetics, when the female patients with multiple (double) CINV risk factors receive treatment with a cisplatin-containing regimen.