2016 Volume 42 Issue 5 Pages 317-327
Preparation of an anticancer drug is usually conducted on a disposable medical sheet (work sheet) in order to reduce pollution in biological safety cabinets (BSCs). However, scattered anticancer drugs might adhere to infusion bags or bottle surfaces placed on these work sheets, and anticancer drug pollution may flow out of BSCs. We have developed a new work sheet incorporated with an adsorbent for anticancer drugs using activated carbon (active carbon sheet) to reduce the pollution outflow from the work sheets and evaluated the ability of the anticancer drug adsorption under experimental conditions.●Prepared solutions of seven anticancer drugs were spilled on the control work sheet and active carbon sheet, followed by placing the infusion bottle or bag on these sheets. The anticancer drug adhering to the infusion bottle or bag surface was collected by a wipe method and subsequently assayed. We then immersed these sheets in anticancer drug solutions and examined the adsorption ability.●The active carbon sheet had only traces of various anticancer drugs adhering to the infusion bottle or bag surface when compared to the control sheets. The concentrations of the anticancer drugs while the active carbon sheet was immersed in the drug solutions were less. The anticancer drug absorbency of the work sheet appears to be critical in preventing anticancer drug outflow from the BSCs to the preparation environment. Use of the new work sheet with active carbon might be beneficial in reducing anticancer drug pollution outflow during preparation.
