Abstract
The Japanese Ministry of Health, Labour and Welfare declared the National Action Plan on Antimicrobial Resistance in 2016 and emphasized the necessity of antimicrobial stewardship. The amount of oral third-generation cephalosporins administered is greater in Japan than in other countries. Therefore, we promoted the proper administration of oral third-generation cephalosporins.
We investigated the changes in prescriptions before and after the approaches of our hospital toward correct administration of antibacterial drugs after day dental surgeries, and their adverse effects, such as the incidence of surgical site infection and changes in costs.
The percentage of prescribed oral third-generation cephalosporins decreased with an increase in penicillin administration; there was a significant difference before and after implementing the approaches (P < 0.01). Due to an increase in penicillin administration, prevention of the development and spread of resistant bacteria was possible.
Furthermore, the incidence of surgical site infection was supposedly not affected and the cost-effectiveness ratio had improved. Efforts toward the appropriate administration of oral third-generation cephalosporins in outpatients have contributed greatly to improving the quality of medical care.
