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Why does Blank Beating of LANTUS® XR Inj. Solostar® Require 3 Units?
2019 Volume 45 Issue 11 Pages 610-615
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2019 Volume 45 Issue 11 Pages 610-615
“LANTUS® XR Inj. Solostar® (450 units / 1.5 mL)” is a preparation that tripled the insulin concentration of existing LANTUS® Inj. Solostar®. As the volume per insulin unit is reduced to one third, the recommended blank beating units before dosing have been increased to 3 units. However, some patients perform 2-unit blank beating as they use the existing injector. A retrospective investigation identified erroneous operation of blank beating in 9.5％ of outpatients who had been prescribed LANTUS® XR Inj. Solostar® at Nagoya Ekisaikai Hospital from April to May 2017. In this study, we investigated if 2-unit blank beating with LANTUS® XR Inj. Solostar® is suitable to confirm needle hole clogging and injection of content by naked-eye observation and the amount emitted. Injection of content was confirmed at the second and subsequent 2-unit beatings by naked-eye observation. On the other hand, the emission weighing test with a new needle and syringe barrel revealed that the amount discharged was increased with 2-unit beating and reached the theoretical value at the fourth beating. Based on these results, we concluded that 3-unit blank beating is preferable for LANTUS® XR Inj. Solostar®; however, three successive 2-unit blank beatings are helpful to confirm correct installation of the needle and normal movement of the injector.
