Relationship between PONV and S-1 Adjuvant Chemotherapy-associated Nausea

Abstract

In this study, we aimed to detect nausea early, reduce nausea and maintain the QOL of patients administered adjuvant chemotherapy with S-1. Therefore, we determined whether PONV (postoperative nausea and vomiting) is a risk factor for nausea in patients treated with S-1 adjuvant chemotherapy. From January 2017 to April 2018, 75 patients who underwent S-1 adjuvant chemotherapy at Ogaki Municipal Hospital were evaluated. Risk factors for nausea in patients administered S-1 adjuvant chemotherapy were examined by multivariate analyses. Twenty-three patients (30.7％) experienced nausea. PONV was not a risk factor for nausea. However, sex (female; odds ratio: 3.98, 95％ CI: 1.11 w- 14.20, P = 0.03),and the loss of more than 9.49％ of weight in both sexes (odds ratio: 3.66, 95％ CI: 1.05 - 12.70, P = 0.04) were risk factors for nausea in S-1 adjuvant chemotherapy. We found that PONV was not a significant risk factor. However, sex (female) and rate of weight-loss significantly increased the risk of nausea associated with S-1 adjuvant chemotherapy.