A Case of Carbamazepine and Esomeprazole-induced Hypocalcemia after Parathyroidectomy

Abstract

We report the case of a patient with carbamazepine- and esomeprazole-induced hypocalcemia after parathyroidectomy. The patient was a 60-year-old man who had undergone pharyngo-laryngo-cervical-esophagectomy and total thyroidectomy for hypopharyngeal cancer. Postoperatively, he had been treated with calcium and vitamin D for hypocalcemia. He recovered completely and was discharged from our hospital. However, he was admitted again to our hospital for hypocalcemia and seizure, which we addressed with an increase of calcium and vitamin D. However, it had no effect on the hypocalcemia. The pharmacists provided drug information about carbamazepine and esomeprazole-induced hypocalcemia to the attending physicians. After withdrawal of carbamazepine and esomeprazole, the levels of serum calcium normalized, and his symptoms resolved.