2022 Volume 48 Issue 12 Pages 545-550
In this study, we investigated whether a combination of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer with commercially available diquafosol sodium (DIQ eye-drops) or sodium hyaluronate eye drops (HYA eye-drops) enhances the therapeutic effect for dry eyes. An N-acetylcysteine-treated rabbit model was used to evaluate the therapeutic effect for dry eyes in this study. The instillation of eye-drops containing DIQ and HYA enhanced mucin levels, and promoted the improvement in the tear film breakup in the N-acetylcysteine-treated rabbit model. In addition, the combination of MPC polymer increased the dry eye therapy in DIQ eye-drops and HYA eye-drops. Although the mucin levels in the N-acetylcysteine-treated rabbit model were also enhanced by the combination of DIQ eye-drops and MPC polymer, the mucin levels were similar between HYA eye-drops co-instillated with or without MPC polymer. These results show that the combination of MPC polymer may enhance the therapeutic effect for dry eyes in commercially available eye-drops.
