Film Material and Influence of the Film Thickness to Give to a Pushing Out Power of the Tablet from Press through Package in Consideration for the Use Characteristics of the Elderly Person

Abstract

I performed examination about the easiness of pushing out of the tablet from press through package (PTP) using the tablet of the ethical drug so far. I manufactured the PTPs that standardized a shape this time and reported influence on easiness of pushing out by the difference of the material of the PTP and film thickness as I considered. The PTPs to become the sample manufactured it using PVC (polyvinyl chloride), PP (polypropylene) or multilayered PO (polyolefin) of the different subject matter. When I pushed a tablet out of these PTPs, the necessary power (squeeze force) was 42, 28, 18 [N] each. Similarly, the film thickness 150, 200, the squeeze force of the PTP of 250 μm were 25, 33, 42 [N] in a PVC material. Furthermore, I did 149 provided patients of the agreement with a subject among the patients who visited the community pharmacy and carried out two kinds of sensory assessment about the easiness of pushing out of the tablet from various PTPs. As a result, it became clear to feel that the elderly person was easy to push PTP of thing using multilayered PO or film thickness 150 μm to material. From this, the spread of PTPs that considered easiness of pushing out and use characteristics in the patients with impaired elderly person and fingers that it was suggested that I can improve usability is expected by difference in material of the PTP or thickness.