1976 Volume 1 Issue 4 Pages 196-199
Japanese Pharmacopoeia (J. P.) requires that the pyrogen test is essential for parenteral solutions. But, in hospital pharmacy, it is practically impossible to perform the official test because of the difficult control of test animals, limited laboratory facilities and timeconsuming procedures. In the study for a simplified checking, a method better than the J. P. pyrogen test was found. The method requires Limulus Lysate, a blood component of Limulus, which is presently applied for the quantitative analysis of endotoxin. The result of this study indicates the possibility of checking pyrogens in parenteral solutions prepared at a hospital pharmacy.