Preparation of Ferromagnetic Microcapsules and Their Effect on Experimental Bladder Cancer

Abstract

Phase separation method has been applied to improve efficiency of magnetic control of ferromagnetic microcapsules. Ferromagnetic mitomycin C microcapsules (FM-MMC-mc.) were prepared by enclosing minimum ferromagnetic ferrite in mitomycin C microcapsules. On the other hand, FM-MMC-mc. was injected into the bladder of rabbits to treat the experimental bladder cancer which had been produced by transplanting V 2 carcinoma. As a result, antitumor effect of FM-MMC-mc. was remarkably higher fhan that of injectable MMC as control. Thus, the efficacy of FM-MMC-mc. was confirmed in this study.