Abstract
Following the previous study, the prediction method of incompatibility in the case of 2 kinds of injection in a single infusion was investigated by estimating the pH of the admixture solution. Data of the previous paper, such as pH characteristic curves (pH titration curves), positive or negative equivalent values (strength of acidity or alkalinity) and values of incompatible pH were also used in the present study.
The pH of the admixture was determined on the pH characteristic curve of the injection having the most dominant buffer action, by plotting the sum of equivalent values for the other 2 preparations. The change in appearance of 2 injections in a single infusion was predicted by comparing the estimated pH of the admixture with the incompatible pH for each of injections.
From the above results, it was confirmed that the inocmpatibility for the admixture of 3 preparations could also be predicted by using pH characteristic curves, equivalent values and values of incompatible pH for each injection.
