Preparation of Ethanolamine Oleate Injection and Its Clinical Application

Abstract

5% ethanolamine oleate (EO) as sclerosant in the treatment of esophageal varices was prepared under various conditions, and the stability of the solution at room temperature for 7 or 8 weeks was studied. Oleic acid in EO was meausred as an indicator for stability of the solution by means of gas chromatograph. It was found that dissolved oxygen-removed EO was more stable than untreated one. Neither treatment of N₂ gas exchange in vial cavity nor autoclaving was essential to keep the content of oleic acid in EO for 8 weeks.
24 (88.9%) out of 27 patients with esophageal varices treated with endoscopic embolization using 5% EO made by our pharmacy were successfully treated. Frequency of complications and abnormal laboratory findings after treatment with the solution showed a rate which is roughly similar to the results reported by other researchers.