1987 Volume 13 Issue 3 Pages 163-167
For topical application to the treatment of Herpes Zoster, dermatologic cream was prepared from capsule form of rifampicin (Rifadin capsule, 150mg/cap) and external preparation of indometacin (Inteban cream, 10mg/g) by direct kneading. The stabilities of indometacin and rifampicin in the cream were studied at room temperature (24±2°C) on exposure to light, at room temperature under shading and in a cold place (13±2°C) under shading, for 28 days. The amounts of indometacin and rifampicin were determined by high-performance liquid chromatography with UV detecter at 254nm.
The visible change in appearance of the cream and the loss in the amount of indometacin were not observed under these conditions at the end of 28 days of storage. The amount of rifampicin was maintained about 80%of its initial content at room temperature after 28 days. While in a cold place under shading, the amount of rifampicin was maintained more than 90%of its initial content during the period of 28 days. It seems that the cream is a relatively stable and useful hospital preparation for the treatment of Herpes Zoster.
