1987 Volume 13 Issue 4 Pages 221-225
As an evaluation of the quality of the sustained release pindolol tablet, the test on dissolution, weight variation, content uniformity, disintegration and hardness were examined. The weight variation of this preparation was 1.2%, the content variation was 19.5 to 20.4mg, the disintegration time variation was 2.54 to 2.60 hours, and the mean hardness was 9.8kg at the outer layer, 10.6kg at the inner core.
In the dissolution test, this preparation showed about 50% dissolution within a few minutes in the first fluid in J.P.X disintegration test, and showed a sustained release pattern in the second fluid in J.P.X. However, their dissolution profiles depended on the pH of the dissolution medium. And the release rate was approximately relative to the rate of stirring.
In addition, disintegration and dissolution tests were examined in the medium with bile salt (sodium cholate) from a consideration of the medium in the gastrointestinal tract, showing that the rates of both the disintegration and the dissolution increased in this medium.
