Compatibility of Berotece^® Syrup in Combination with Other Liquids

Abstract

Compatibility of Berotec^® syrup (preparation of fenoterol hydrobromide) in combination with other liquids was studied in terms of changes in pH and appearance, together with high performance liquid chromatographic determination of fenoterol content.
In the combination with Pontal^® syrup, decrease of redistribution was observed, while in that with Brocin^® solution, appearance of a cotton-like substance was observed. Furthermore, in the combinations with Brocin^® solution and Brocin^®-Codeine Syr. Conc., decrease of fenoterol content was found. The results indicate that these three liquids are imcompatible with Berotec^® syrup.