アフェレーシスにより採取した血小板製剤の白血球除去に関する検討

石川 裕子; 平井 耕作; 前田 和子; 高倉 利美子; 植田 米男; 高柳 美行; 近藤 澄子; 長谷川 岩三; 後藤 鉦二; 福田 常男

doi:10.5649/jjphcs1975.14.1

Study for the Removal of Leukocytes from Platelet Products Collected by Apheresises

YUKO ISHIKAWA, KOSAKU HIRAI, KAZUKO MAEDA, RIMIKO TAKAKURA, YONEO UEDA, MIYUKI TAKAYANAGI, SUMIKO KONDO, IWAZO HASEGAWA, SHOJI GOTO, TSUNEO FUKUDA

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Keywords: apheresis' PC, concentration of leukocytes, Imugard filter, centrifugation, platelet recovery, leukocyte removal, reservation of platelets' functions

JOURNAL FREE ACCESS

1988 Volume 14 Issue 1 Pages 1-6

DOI https://doi.org/10.5649/jjphcs1975.14.1

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Abstract

Since apheresises and blood collection systems were acknowledged by the Ministry of Public Welfare in Japan in April 1986, a lot of plasma or platelet products have been collected from volunteers by these systems. Among these platelet products, platelet rich plasma (PRP) and platelet concentrate (PC) have an apparent weak point which is the contamination of many leukocytes (10⁷-10⁹/bag). Therefore we studied the removal of leukocytes from the apheresis' platelet products by the following two methods and the following results were obtained.
1) The centrifuging method:
The recovery of platelets: 78.9%, The removal of leukocytes: 88.4%.
2) The Imugard filter method:
The recovery of platelets: 89.0%, The removal of leukocytes: 96.0% or more, Thefunctions of platelets: normal.

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