Abstract
The purpose of this study is to investigate the influence of food on pharmacokinetics and pharmacodynamics of furosemide after oral administration of at ablet (40mg) 30 minutes before or after breakfast to three healthy male volunteers by measuring plasma concentrations and excretion rates in urine.
The results showed that the pharmacokinetic parameters Cmax, tmax, MRT0-8 (mean residence time) and AUC0-8 after administration of furosemide before breakfast were significantly different from those after breakfast.Higher volume of urine was observed immediately after oral administration of furosemide before breakfast than that after breakfast, while cumulative volume of urine within a 24-hour period was not significantly different between those before and after breakfast.Therefore, old-age patients with hypertension should be careful when they take furosemide before a meal because of the sudden diuretic effect of furosemide.
