Pharmaceutical Evaluation of Sodium Valproate Fine Granules

Abstract

Compatibility of sodium valproate (SV) fine granules with phenytoin, caffeine and sodium benzoate, acetylpheneturide, dried yeast, trimethadione or Cabagin-U^® was investigated by highperformance liquid chromatography.
Changes in compatibility were observed in the mixtures of SV with almost drugs except for Cabagin-U^® under the severe conditions (25°C, RH 75%).
These results, suggest that Cabagin-U^® is the suitable drug in mixing with SV.And then, since SV may be administered for as long as 30 days, caution should be exercised in mixing this drug with other agents.