Pharmaceutical Studies for Long-term Stability of Vitamins in Intravenous Hyperalimentation Solutions Prepared in Clean Room

Abstract

For the purpose of supply of intravenous hyperalimentation solutions (IVH) for home care, we examined long-term stability, especially vitamins B₁, B₂, C and A for two weeks to monitor changes in hospital coded prescription, IVH 1-5.
Decrease of vitamin B₁ was observed in IVH 1-4 with time.It was decreased by 27.0-40.5 % on the 14th day, while in IVH 5 the concentration decreased to at 83.7%.Vitamine C showed the next largest decrease to 65.1% being retained two weeks in IVH 5.In IVH 1-4, on the other hand, it remained at 83.6-94.4%.Other two vitamins B₂ and A remained stable at the comparatively high level of 80.9-101.4% in each preparation.
From the results, it is seemed that if the constituents of IVH are given sufficient consideration, it would be possible to guarantee the long-term stability of IVH with vitamins in the index of vitamins B₁ and C.