Abstract
Pharmacokinetics of MTX in seven osteosarcoma patients treated with 36 courses of high dose MTX therapy was investigated.Serum concentrations of MTX were well fitted to 3-compartment model.The slopes of γ phase were significantly correlated with the counts of leukocytes (r=0.65, p<0.001), and also the mean γ value in the patients suffering the adverse reactions was significantly smaller than that without any adverse reactions (p<0.05).