Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Pharmacokinetics of High Dose Methotrexate (2)
TEIKO TOYOGUCHIHIDEYO NAGAOKASHU ISIKAWAYOSHITO NAKAGAWA
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1990 Volume 16 Issue 2 Pages 101-106

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Abstract
Pharmacokinetics of MTX in seven osteosarcoma patients treated with 36 courses of high dose MTX therapy was investigated.Serum concentrations of MTX were well fitted to 3-compartment model.The slopes of γ phase were significantly correlated with the counts of leukocytes (r=0.65, p<0.001), and also the mean γ value in the patients suffering the adverse reactions was significantly smaller than that without any adverse reactions (p<0.05).
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© Japanese Society of Pharmaceutical Health Care and Sciences
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