Abstract
Stabilities of steroids admixed with or without Alevaire ® or Bisolvon ®, which were treated with ultrasonic nebulization (UN), compressor nebulization (CN), or incubation at 45°C, were investigated with regard to its changes in appearance, pH, and residual potency.In this study, the following steroids were used: hydrocortisone sodium succinate (HC), prednisolone sodium succinate (PS), methylprednisolone sodium succinate (MPS), dexamethasone disodium phosphate (DM), betamethasone disodium phosphate (BM) and flunisolide (FS).
The results are summarized as follows;
1) No changes in pH were observed in all solutions of steroids admixed with or without Alevaire or Bisolvon, with treated with UN or CN and incubated at 45°C.But HC, PS, MPS and DM became turbid soon after admixing with Bisolvon ®.2) The residual potency of all steroids treated with CN for 30 minutes were maintained above 90%.3) The residual potency of HC, PS and BM treated with UN for 30 minutes tended to decrease below 90%.Also, the residual potencies of HC and PS in admixture with Alevaire ® or Bisolvon ®, BM in admixture with Alevaire ®, and MPS in admixture with Bisolvon ® treated with UN for 30 minutes tended to decrease.These results indicate that the use of UN is inadequate to steroids anemopathy of HC, PS and BM, and CN is recommendable for the treatment.
