The Postantibiotic Effect of Several Kinds of Antibiotics against E.coli, and Producing Ability of Bacterial β-glucuronidase In vitro

Abstract

The postantibiotic effect (PAE) of four kinds of antibiotics (Chloramphenicol, Gentamicin Sulfate, Cefazolin Sodium, Ampicillin) against Escherichia coli (E.coli) and the producing ability of bacterial β-glucuronidase in vitro were measured.The PAE was found in two kinds of non β-lactam antibiotics, and the β-glucuronidase production of E.coli was suppressed during the term of PAE.
These results suggest a promising development for PAE measurement against E.coli by utilizing β-glucuronidase produced by the organisms.