1992 Volume 18 Issue 3 Pages 293-298
A plastic bag, which is composed of 3 layers i.e.polypropyrene, nylon and polyester films, has been devised for sterilization of liquid preparations for external use by an autoclave.Physico-chemical tests such as heavy metal, nonvolatile residue and water vapor permeation were carried out to evaluate the suitability as a container for liquid preparations.The adsorption of chlorhexidine gluconate and benzalkonium chloride from aqueous solutions to the plastic bag was investigated.
This bag was adopted for the requirements under physico-chemical tests for plastics.There was no decrease of chlorhexidine gluconate or benzalkonium chloride by adsorption to the plastic bag under autoclaving at 115°C for 30min, and subsequent storage at room temperature for 4 weeks.It was suggested that the newly-devised plastic bag was very useful for sterilization of liquid preparations in hospital pharmacy.
