The Effect of the Drip Condition (Drip Rate, Concentration) on the Leaching of Diethylhexyl Phthalate from the Administration Set into the Intravenous Cyclosporine Solutions

Abstract

We investigated the effect of the drip condition on the leaching of diethylhexyl phthalate (DEHP, a plasticizer of polyvinyl chloride) from a parenteral infusion set into the intravenous, cyclosporine solutions.The concentration of DEHP was measured by high-performace liquid hromatography.The factors effecting on the leaching of DEHP during infusion were the drip rate and the concentration of injection.When the cyclosporine solutions were passed through the administration set, 100cm in length at a flow rate of 0.58ml/min, and initial cyclosporine concentration of 500μg/ml, the total amount of DEHP released up to 180 minutes was 578μg.