Abstract
The complex formation between pyrazinamide and isoniazid was studied in the Higuchi Lach method. The solubility of pyrazinamide increased in parallel with isoniazid concentration at 25°, indicating a complex formation. The increase in solubility of pyrazinamide is due to a complex formation and continues until the solubility of the complex reaches the limit. The results of the experiment indicate that the complex is formed by pyrazinamide and isoniazid mixed at equal ratio. This is substantiated by the finding that the equilibrium constant in the experiment remained stable in the whole range of concentrations.
