Abstract
This study was undertaken to ascertain the total indexes of adverse drug reaction and with these indexes to clarify the characteristics of adverse reaction to individual antibiotic. The frequencies of adverse reaction in 14 sites were calculated by the accumulative data of 22 antibiotics obtained from clinical trials and post-marketing surveillance which were reported by the Ministry of Health and Welfare. They were examined by principal component analysis.
The results were as follows: 1. There were strong intercorrelations in the frequencies of adverse reactions which affect the whole body in general inclusive of the hepatobiliary system and blood. 2. The first and second principal components were suggested to reveal the frequencies of adverse drug reaction affecting the whole body, and affecting local regions such as the ear, application site and urinary system, respectively. Their cumulative proportion was 61.4%. 3. The first principal component score tended to be larger in parenteral cephems, whereas the second principal component score tended to be larger in aminoglycosides. 4. The first principal component score of ceftizoxime sodium constituted the largest extreme. 5. The frequency of adverse reaction to fosfomycin which affected the whole body was obserbed to decrease by changing Na salt to Ca salt.
