Pharmacokinetics of Non-ionic Contrast Medium Iohexol in Hemodialysis Patient

Abstract

In the present study, blood concentrations of iohexol were measured in hemodialysis patients and in subjects with renal dysfunction in order to determine the hemodynamic and dialytic features of iohexol. Adverse reactions to the agent were also investigated.
The subjects were six inpatients, including three hemodialysis patients with mild-to-moderate renal dysfunction, who were given iohexol at our hospital. Iohexol concentrations in serum and dialysate were measured using HPLC. The T_1/2 in hemodialysis patients was 78.81±43.83 hr in the γ phase and 2.41±1.27 hr during hemodialysis. The elimination rate was 59.4±8.3% and the clearance rate was 98.8±25.3 ml/min 2 hr after the start of hemodialysis. No adverse reactions were observed in the hemodialysis patients.