Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Water Vapor Permeation of Child Resistant Package
MASATO HIDAKAYOSHIKO TANAKAATSUSHI WATANABEMASAYASU SUGIHARA
Author information
JOURNAL FREE ACCESS

1995 Volume 21 Issue 2 Pages 115-123

Details
Abstract
The water vapor permeation behavior of the child resistant package (CRP) with a pressand-turn closure, the polyethylene bottle with a screw cap and the glass bottle with a screw cap was investigated. The water vapor permeation increased in the order of the glass bottle, polyethylene bottle and CRP. The amount of water vapor permeated through the CRP showed a linear increment with the passage of time. The effect of applied sealing torques on the water vapor permeation was also investigated. There was not affect on the water vapor permeation of glass bottle and little influence on the of the polyethylene bottle. On the contrary, the water vapor permeation of the CRP showed dependency on the applied sealing torque. These results suggest that the differences in water vapor permeation were due to the specific structure of the CRP closure. Additionally revealed was that in the CRP the relationship between the log applied sealing torque and the water vapor permeation rate produced a nearstraight curve.
Content from these authors
© Japanese Society of Pharmaceutical Health Care and Sciences
Previous article Next article
feedback
Top