Abstract
The fibrinolytic activities of commercially available urokinase were compared using a platelet aggregometer, which is capable of measuring the change in turbidity during the fibrinogen dissolution process.
The fibrinolytic activities were evaluated from the half-lives of the turbidity ratio at 660 nm using fibrin as a plasmin substrate. A clear linear relationship was evidenced between the half-life of the turbidity ratio and fibrinolytic activity, conforming that this method is superior to others with regard to accuracy, sensitivity, reproducibility, and quickness of measurement.
Furthermore, no difference was seen between the fibrinolytic activities of two commercially urokinase preparations. In conclusion, the platelet aggregometer was found to be very useful devise for evaluating the fibrinolytic activity of urokinase.
