The Correlation between the Quantity of Antibiotics Utilized and the Number of Methicillin-resistant Staphylococcus aureus (MRSA) Isolated in Nagasaki University Hospital

Abstract

The relationship between the quantity of antibiotics utilized in classification and the number of cases of methicillin-resistant Staphylococcus aureus (MRSA) in Nagasaki University Hospital was retrospectively investigated during the June 1993 May 1995 period. Notably, the yearly quantity of the third generation cephems gave a good correration for the yearly number of MRSA isolates. In addition, a significant correration was observed for the monthly quantity of the antibiotics which could extend to MRSA using Spearman's rank correlation. The successive terms of the use of monobactums appears to be closely related to an increase in the number of MRSA isolates on statistical consideration. These observations demonstrate the need to limit the furthe rspread of resistance to nosocomial infection.