Abstract
The availability of a method for predicting pH changes in multiple admixtures based on the acid-base equilibrium theory has been confirmed comparing the calculated pH's and the measured pH's in the admixtures of transfusions mixed with two or more injections. The pH's of the parenteral admixtures can be easily predicted by using a general theoretical equation for proton concentrations in a multicomponent-blended aqueous solution without any preliminary pH titration. The pH's of 59 injections and 26 transfusions were compared with pH's of the drugs described in the information leaflets. Three hundred and ninety-seven transfusions and parenteral solution mixture combinations (one transfusion and two injections) were examined for the efficacy of the predicted equation. As a result, the estimated pH closely agreed with the measured pH in all examinations, and a good correlation existed between the measured and calculated values of pH. Furthermore, to estimate the pH's of transfusions mixed with multicomponent injections, good agreements were also observed between the measured pH's and calculated pH's in any preparations with different mixing orders.
