Abstract
Administration of H2-brocker with “multi-vitamin” (mixed vitamin preparations for IVH) as constituents of the IVH admixture is important for the patient developing anastomatic ulcer following surgical operation.
Time courses of each consistuent concentration, such as that of famotidine as H2-blocker and various vitamins, were assayed using HPLC (high performance liquid chromatography). The data were evaluated by means of Weibull plot method. As a results, famotidine was found not stable in both heated acidic and basic solutions, but is stable in neutral solution. In case of the IVH admixture, V.B1 is regarded as a key vitamin of stability of solution, and light-protection was not effective in V.B1 stability. No distinctive interaction was noted between famotidine and vitamins. The kinetic rate in the degradation process of vitamins and famotidine were evaluated using the Weibull-plot method under the conditions of controlled room temperature, use no protective film, and refrigeration. Thefitting precision of the Weibull-function is more accurate than thefirstorder and zero-order decay function, and which is more applicable as a stability nomogram.
