Abstract
Recombinant human granulocyte-colony stimulating factor (rhG-CSF) is administered either by i. v. drip infusion or a subcutaneous injection depending on the indications for which it is administered. In the case of i.v. drip infusion, binding to the infusion set and in-line filter has great impact on its efficacy because it is given in very small doses (micrograms). In the present study, we conducted a series of experiments to deterrmine the degree to which rhG-CSF binds to infusion containers, sets, and filters. The Pall PD1 Filter with a low protein binding profile was thus found to be the only infusion filter through which commercially available rhG-CSFs could almost be completely recovered regardless of the solvents used.
