1999 Volume 25 Issue 3 Pages 323-329
To ensure the quality of sterilized IVH preparations, we attempted to predict the pH of the admixture using Shoji's method (a method of for predicting incompatibility when admixing injections for infusion) and Iseki's method (a method for multiple admixture based on the acid-base equilibrium theory).
Furthermore, we also carefully measured the endotoxin levels in IVH.
A significant correration between the estimated pH and the measured pH (n=19) was observed in both Shoji's (r=0.9761) and Iseki's method (r=0.9849). In addition, the injected levels were determined by dilution with any sterile water and evaluated after recovering any added endotoxin in IVH. As a result, we recovered more than 80% of the endotoxin from the diluted IVH solution.
