Abstract
Preparations of lithium carbonate, owing to the strong alkalinity of the agent, must be manufactured in enteric coated tablet. The composition and conditions of the manufacture of enteric coated tablet of lithium carbonate was studied. A tablet compounded by direct compression of lithium carbonte, Avicel, Perfiller and CMC-Ca in the ratio of 100: 20: 20: 1 proved most excellent in respect of disintegration time, dissolution rate, tablet hardness and standard deviation. A tablet coated with EC101 over the core covered with FC101 in equal weight to that of the tablet was freely disintegrated in alkaline test solution but not in acid test solution. Caution should be taken against humidity effect, since the disintegration of moistened tablet is hindered in alkaline test solution.
