Abstract
Photodegradation of vitamin K1 and K2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10mg) of vitamin K1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2, 000 lux) for 3 hours was 43-63% for K1 and 31-44% for K2. Therefore, intravenous admixtures containing theselight-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.
