Abstract
Compatibility of futraful (FT-207) fine granules with 54 commercial preparations was tested under three conditions of constant temperature and relative humidity (A: 30°, 92%; B: 23°, 76%; C: 5°, 50%). As a result, no change was observed in FT-207 fine granules and 30 of 54 preparations under any condition. Some changes such as wetness, coagulation, coloration and liquefaction were observed in 24 preparations under condition A, 11 preparations under condition B and 2 preparations under condition C. Of 24 preparations, the following 4 preparations were considered to develop changes when compounded with FT-207 fine granules magnesium oxide, aminophylline, galantase and sodium bicarbonate. By thin layer chromatography, the decomposed compound (5-fluorouracil) of FT-207 was detected in combination with 10 preparations such as enzyme and vitamin. The rate of decomposition of FT-207 allowed for 30 days under condition A was 2.5-5 % in combination with Popon S and less than 1% in combination with other 9 preparations. But these changes in appearance and potency of FT-207 with packing were less than that without packing. Any of 54 preparations are thought to be compoundable with FT-207 fine granules when sufficient care is taken to protect them from moistening.
