Abstract
Compatibility of 10% pantethine injection (Pantosin in 2-ml ampule) with 103 kinds of commercial preparations which were frequently prescribed with pantethine injection in our hospital was examined in terms of changes in external appearance and in pH of the mixed solutions.
By thin layer chromatography (TLC) and high-pressure liquid chromatography (HPLC), chemical change and residual pantethine were examined after standing for 24 hours. The results showed precipitation in 3 combinations, color change in 2, unknown spot on TLC in 1, and rapid decrease in volume of pantethine in glutathione preparations. These results suggested that careful attention should be paid to the above combinations. However, in all the remaining 95 combinations with other preparations, the external appearance, change of pH and decrease in pantethine volume were very small, indicating excellent stability.
