Abstract
Syrup is originally intended to be used as unmixed and undiluted solution. In Japan, the product is mostly administered in combination with other agents and as water-diluted solution. Change upon combination and stability of Pontal Syrup was studied. Test samples were prepared by combining Pontal Syrup in daily pediatric dose with each of 15 other kinds of syrup and adding water to make 25 ml. Stability, IR spectrum, antibacterial action and other properties of the samples were tested. Upon combination with Pontal Syrup, change in appearance and reduction in potency were noted in a few agents.
