Compatibility of Sodium Ampicillin for Injection on Its Mixture with Other Drugs

Abstract

The potency of ampicillin is known to be reduced when mixed with glutathione. Halogen or sulfonic acid group is related to the detoxication mechanism of Tathion. In this study, mixtures were prepared first by dissolving Tathion in halogen -or sulfonic acid groupcontaining injections such as Allergin, Metilon and Adona.Then the effect of Viccillin for injection, an ampicillin preparation, added to the mixtures, was examined by bioassay and colorimetry. It was found that the potency of Viccillin is well preserved by adding Allergin, Metilon or Adona mixed with Tathion.